Reminiscence Therapy

Ageing Research Reviews 5 (2006) 113 www.elsevier.com/ square up off/arr Review Age-related neuropathology, cognitive settle, and Alzheimers distemper Jeffrey N. Keller * department of Anatomy and Neurobiology & Sanders-Brown Center on Aging, University of Kentucky, 800 South Limestone, Lexington, KY 40536-0230, USA reliable 6 May 2005; standard in revised pretend 14 June 2005; judge 15 June 2005 Abstract In the cultivation 20 years, in that location put one everywhere been tremendous strides made in the mind of the molecular and cellular processes that occur during brain aging, as well as our understanding of agerelated disorders of the central nervous system (CNS). Aging is associated with a free fall in cognitive performance, and is the biggest risk factor for the ripening of Alzheimers sickness (AD), although the underlying basis for twain of these observations is poorly de?ned. both normal aging and AD are associated with overlapping and victimisat ion levels of pathology. Numerous reports have now linked elevations in pathology as potentiality mediators of cognitive decline in the elderly, with most studies concentrate on on the role of AD-related pathology.

However, it is important to point out that there are numerous other pathological features observed in the aging brain including corpora amylacea, argyrophilic grains, neuromelanin, and lipofuscin. In this review, I discuss the reduced cognitive performance observed during normal aging, the potential for pathology to transmute neuronal function and neuronal viability during normal brain aging, and the potential for common pathologies to either inhibit or promote the! development of age-related disorders such as AD. # 2005 Elsevier Ireland Ltd. All rights reserved. Keywords: Aging; Alzheimers disease; Argyrophylic grains; Cognitive reserve; Lipofuscin; Neuromelanin; Oxidative stress 1. Introduction It is broadly speaking accepted that during normal brain aging there is a gradual and progressive loss of cognitive performance. Studies have...If you want to push a full essay, order it on our website: BestEssayCheap.com

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